Burgess RR (2018) A brief practical review of size exclusion chromatography: rules of thumb, limitations, and troubleshooting.Arakawa T, Ejima D, Tsumoto K, Obeyama N, Tanaka Y, Kita Y, Timasheff SN (2007) Suppression of protein interactions by arginine: a proposed mechanism of the arginine effects.GE Healthcare Life Sciences (2015) Capto™ MMC ImpRes.GE Healthcare Life Sciences (2013) Polishing of monoclonal antibodies using Capto™ MMC ImpRes in bind and elute mode.Chmielowski RA, Meissner S, Roush D, Linden TO, Glowacki E, Konietzko J, Nti-Gyabaah J (2014) Resolution of heterogeneous charged antibody aggregates via multimodal chromatography: a comparison to conventional approaches.Gao D, Wang LL, Lin DQ, Yao SJ (2013) Evaluating antibody monomer separation from associated aggregates using mixed-mode chromatography.Chen J, Tetrault J, Zhang Y, Wasserman A, Conley G, Dileo M, Haimes E, Nixon AE, Ley A (2010) The distinctive separation attributes of mixed-mode resins and their application in monoclonal antibody downstream purification process.Eriksson K, Ljunglöf A, Rodrigo G, Brekkan E (2009) MAb contaminant removal with a multimodal anion exchanger: a platform step to follow protein A.Gagnon P, Beam K (2009) Antibody aggregate removal by hydroxyapatite chromatography.Gagnon P, Ng P, Aberrin C, Zhen J, He J, Mekosh H, Cummings L, Richieri R, Zaidi S (2006) A ceramic hydroxyapatite based purification platform: simultaneous removal of leached protein A, aggregates, DNA, and endotoxins.coli inclusion bodies using mixed-mode resin, Capto MMC was. See also Figure 3.1 ( Multimodal chromatography media) and its accompanying discussion of pressure-flow properties. McCue JT (2009) Theory and use of hydrophobic interaction chromatography in protein purification applications. Toyopearl NH2 750F (b) Capto adhere and (c) HEA HyperCel mixed mode resins. Capto MMC is based on a highly rigid agarose base matrix that allows high flow rates and low back pressure at large scale, and is well-suited for fast, efficient and cost-effective protein purification.Lu Y, Williamson B, Gillespie R (2009) Recent advancement in application of hydrophobic interaction chromatography for aggregate removal in industrial purification process.McCue JT, Engel P, Ng A, Macniven R, Thömmes J (2008) Modeling of protein monomer/aggregate purification and separation using hydrophobic interaction chromatography. ![]() Zhang X, Chen T, Li Y (2019) A parallel demonstration of different resins' antibody aggregate removing capability by a case study.He X (2015) Mixed-mode chromatography for mAb S aggregate removal: comparison of CHT™ ceramic hydroxyapatite, capto adhere, and capto adhere impres.Hall T, Wilson JJ, Brownlee TJ, Swartling JR, Langan SE, Lambooy PK (2015) Alkaline cation-exchange chromatography for the reduction of aggregate and a mis-formed disulfide variant in a bispecific antibody purification process.Vázquez-Rey M, Lang DA (2011) Aggregates in monoclonal antibody manufacturing processes. ![]()
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